SILICIFIED MICROCRYSTALLINE CELLULOSE, MODERN CO-PROCESSED EXCIPIENT FOR LOW DOSE SOLID DOSAGE FORMS.
Monika Tomar*, Jilika Shah, Amit Raj Sinha and Ajay Kumar Singh
ABSTRACT
Low dose 75 mg aspirin tablets are widely used for adults in arthritis, rheumatic fever, pain and to reduce uric acid excretion. Low dose formulation are manufactured by wet granulation method, which is time consuming and laborious. However these days direct compression method is in trend. Direct compression method is cost effective and gives better productivity than wet granulation method. Micro-crystalline cellulose and silicified micro-crystalline cellulose are suitable excipients for direct compression method. Silicified microcrystalline cellulose is favorable for low dosage forms. It controls drug content uniformity in the tablets. Silicified microcrystalline cellulose has outstanding flow-ability, when it is mixed with API, material fills into die equally during tableting. In this study, we compared SEM analysis, flow-ability and tablet profile of Silicified microcrystalline cellulose with microcrystalline cellulose. We used HiCelTMMCC and HiCelTMSMCC to evaluate this study. Physical properties of HiCel™SMCC are novel for low dose tablet.
Keywords: SEM analysis, Flow fraction, Mohr’s stress circle, weight variation, content uniformity of drug,
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
