European Journal of Biomedical and Pharmaceutical Sciences

THERMODYNAMIC STUDIES OF PARACETAMOL AND ASPIRIN IN ALCOHOLIC SOLUTION AT DIFFERENT TEMPERATURE.

*R. R. Tayade

ABSTRACT

Density and viscosity measurements are reported for alcoholic solutions of the drugs like paracetamol & aspirin at different temperatures T = (300.15, 310.15 and 320.15) K within the concentration range (1x10-2 M to 6x10-4 M). The density and viscosity data are used to obtain specific viscosity and relative viscosity of different concentrated alcoholic solutions at different temperatures. Jones–Dole equation for viscosity is used to calculate A and B coefficients. The results obtained have been interpreted in terms of solute–solvent and solute–solute interactions and structure making/breaking ability of solute in the aqueous solution. The thermodynamic properties such as free energy change(ΔG), enthalpy change(ΔH) and entropy change (ΔS) of paracetamol & aspirin drugs have been investigated in pure alcoholic medium at different temperature such as (300.15,310.15 and 320.15) K. The experimental data gives the idea about effect of temperature on the molecular interaction and structural changes in solute.

Keywords: Density, relative viscosity, specific viscosity, thermodynamic parameters, solute-solvent interaction.