European Journal of Biomedical and Pharmaceutical Sciences

NAPROXEN DISSOLUTION IMPROVEMENT BY PREPARATION OF SOLID DISPERSIONS WITH CYCLODEXTRIN COMPLEX’S

Dr. Rohini Pilli*, SDVS Kiran Kadali and Dr. M. V. Nagabhushanam

ABSTRACT

Naproxen is an anti-inflammatory drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of Naproxen by using solid dispersions (SDs) in hydrophilic polymers .The solid dispersions were prepared with a Co-evaporation,kneading & Physical Mixture methods using different concentrations of β -cyclodextrin (β-CD). The release of Naproxen from various solid dispersions was determined from dissolution studies by use of USP dissolution apparatus II (paddle method). The dissolution study results revealed that there was a considerable increase in solubility and dissolution of all solid dispersions as compared to pure drug. Prepared Solid dispersions were characterized by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD), and infrared spectroscopy (IR) and SEM images were evaluated for drug content, saturation solubility. Physicochemical characterization of solid dispersions suggests a reduction in drug crystallinity following dissolution enhancement. Results indicate that present %DE 30 of drug was improved from 22.38 to 79.22 by the use of Naproxen β-CD-HPMC (1:2:0.3) Kneaded complex.

Keywords: Naproxen Solid dispersions, hydrophilic polymers.