EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF ETHANOL LEAF EXTRACT OF ORIGANUM MAJORANA AND VITEX NEGUNDO ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Bimala Tripathy*, S. Satyanarayana, K. Abedulla Khan, K. Raja and Shyamalendu Tripathy
ABSTRACT
Medicinal plants are considered as rich resources of ingredients which can be used in new drug development in pharmacopoeial, non-pharmacopoeial or synthetic drug. To compare anti-hyperglycaemic effect between two ethanolic extracts of selected plants locally available in Bobbili region, Vizianagaram district, Andhra Pradesh, India on Streptozotocin induced diabetic rats. To compare anti-hyperglycaemic study, experimental rats were divided into six groups viz. Group I (Normal control), Group II (Disease control, Streptozotocin induced, 50mg/kg b.wt, i.p.), Group III (Diabetic with Glibenclamide, 4mg/kg), Group IV (Diabetic with Origanum majorana ethanol extract) and Group V (Diabetic with Vitex negundo ethanol extract). Both plants extracts were administered with same dose i.e. 100mg/kg b.wt, orally. The blood glucose levels, lipid profile, body weight were evaluated in all above experimental groups before and after diabetes induction in 21 days study. Significantly decreased blood glucose level and simultaneously improved lipid profile and body weight in Group IV rats after oral administration of ethanol extract whereas in Group V rats are showing less effect compare to Group IV rats. Both the plant extracts effect compare with Group II and Group III rats statistically. Origanum majorana shows better antihyperglycaemic activity because the leaf contain huge amount of phytoconstituents like rutin and quercetin isolated flavonoids. In Vitex negundo leaves ethanol extract also shows antihypoglycaemic activity because it contains 1,2- disubstituted idopyranose, β-sitosterol like active constituents. Origanum majorana and Vitex negundo plants may be used as a dietary supplement in diabetic patients. Further study is required to evaluate the antihyperglycaemic activity.
Keywords: Origanum majorana, Vitex negundo, Hyperglycaemia, Phytoconstituents.
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