Abstract
ADVERSE DRUG REACTIONS TO ANTI-RETROVIRAL THERAPY: A CROSS SECTIONAL OBSERVATIONAL STUDY

Dr. Yogananda Rajashekharachar, Dr. Manoj Kumar Mudigubba*, Dr. Pathan Amanulla Khan, Dr. NagendraGowda MR, Dr. Bharathi Doddlu Raghunathnaidu and Sowmya M

ABSTRACT

Human immunodeficiency virus/Acquired Immune Deficiency Syndrome is a fatal illness which leaves the victim to a lot of life threatening Opportunistic infections, Neurological disorders, malignancies. Objectives: To evaluate the incidence, risk factors associated with adverse drug reactions (ADRs) and analyze these adverse drug reactions by using naranjos scale questionnaire among patients on antiretroviral drugs. Materials and methods: A Cross- sectional Observational study was carried out in People Living with HIV& AIDS attending antiretro viral therapy centre in a Chitradurga district, Karnataka state, India for a period of six months. A total of 599 patients were enrolled into the study. Chi square test was used to detect the association status of different variables. Results: Our study results shows that, a total of 599 [100%] patients were enrolled in to the study, out of them 155 [25.9%] came across with adverse drug reactions. The incidence of ADR was 1 in every 6 patients on antiretro viral therapy with in a period of 6-12 months. Major risk factors considered in this study were age, gender, CD4 count, treatment regimen, duration of treatment, tobacco smoking and alcohol. Conclusion: Adverse drug reactions were more likely to occur in the first one year of treatment. Close monitoring with in this period is required to prevent occurrence of severe adverse drug reactions and can improve medication adherence.

Keywords: Adverse drug reaction, ART, PLHAs, HIV/AIDS, Incidence, Risk factors.


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