ISOLATION AND EVALUATION OF STARCHES AS EXCIPIENTS IN THE FORMULATION OF TABLETS
Rahul Wankhade*, Kawtikwar P. S. and Indurwade N. H.
ABSTRACT
The aim of this investigation was to find the alternatives to the presently used starches in Pharmaceutical Industry. The starches isolated from the different raw materials such as Bhagar, Sweet potato, Sago, Bajra, Banana were compared with the Corn starch (widely used in the Pharmaceutical and other industries) with respect to the cost, properties as a Pharmaceutical excipient and availability. Starches were isolated from five different sources. These sources were,1) Bhagar starch, obtained from the grains of Panicum Miliaceum, (Family: Graminae), 2), Sweet potato starch, obtained from the grains of Ipomoea batata, (Family: Convolvulaceae), 3) Sago starch, obtained from the pulp of the trunk of Metroxylon rumphii (Family: Palmae), 4) Bajra starch, obtained from the grains of Pennisetum typhoides (Family: Graminae), 5) Banana starch, obtained from the unripe pulp of fruit Musa paradisiaca (Family: Musaceae). These isolated starches were studied as an excipients in the formulation of tablets. Tablets of diclofenac sodium were prepared using these isolated starches as disintegrant in the concentration of fifteen and ten percent respectively. The physical properties of these tablets were studied to evaluate the diluents, binding and disintegrating properties of isolated starches. It was observed that Bajra starch has good white colour, lowest cost of raw material, lowest projected cost and better disintegration time. Therefore, it can be considered as best alternative for corn starch.
Keywords: Bhagar starch, Sweet potato starch, sago starch, bajra starch, banana starch, diclofenac sodium.
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