European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND CHARACTERIZATION OF MONTMORILLONITE - PLGA COMPOSITE AS DELIVERY VEHICLE FOR EXTENDED RELEASE OF METRONIDAZOLE

Arun Kant and Monika Datta*

ABSTRACT

The aim of the present work is to develop a clay based delivery vehicle for system comprising of Montmorillonite (Mt)-PLGA [poly (D, L-lactide-co-glycolide)] composite material to be used as extended release of an antibiotic drug Metronidazole (MTZ). PLGA-MTZ and Mt-PLGA-MTZ composite material were synthesised using different methodologies including single emulsion solvent evaporation (SESE), double emulsion solvent evaporation (DESE) and double emulsion solvent diffusion method (DESD). The synthesized PLGA-MTZ and Mt-PLGA-MTZ composite has been characterized using analytical techniques including X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Transmission Electron Microscopy (TEM) and Scanning Electron microscopic (SEM) imaging with EDX analysis. The in-vitro release behaviour of the drug of pure MTZ, synthesized PLGA-MTZ and Mt-PLGA-MTZ composite by different methodologies were investigated in the simulated gastric and intestinal fluids. In the present case possible bioavailability for pure MTZ, PLGA-MTZ and Mt-PLGA-MTZ composites has been calculated from the in- vitro drug release data and compared to the pure MTZ and the commercially available tablets.

Keywords: MTZ, Mt, PLGA, SESE, DESE, DESD and extended release.