European Journal of Biomedical and Pharmaceutical Sciences

GSTM1 POLYMORPHISM IN SUDANESE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

Ebtga El Hady and Ibrahim Khider Ibrahim*

ABSTRACT

Background: Glutathione S-transferase enzymes that play a key role in detoxification of activated carcinogens are shown to be one of the potential modifiers of individualized risk for several cancer types. Objective: This purpose of this study was to investigate the frequency of the GSTM1 null genotype in chronic lymphocytic leukemia patients in Sudan. Material and methods: Fifty chronic lymphocytic leukemia patients and fifty controls were evaluated to determine the frequency of gstm1 null genotype. The GSTM1 null genotype was determine using polymerase chain reaction (PCR) method. Results: The GSTM1 null polymorphism was detected in 38% of cases and 36% of control subjects (table1) but the difference was statistically significant (or=2.9 95% C l = 1.28 -6.5, p=0.01) therefore GSTM1 null genotype may be a risk factor for CLL. (P. value =0.01). Conclusion: In summary we concluded that GSTM1 null polymorphism is a risk factor for CLL among Sudanese patients.

Keywords: Background: Glutathione S-transferase enzymes that play a key role in detoxification of activated carcinogens are shown to be one of the potential modifiers of individualized risk for several cancer types. Objective: This purpose of this study was to inve