MEASUREMENT OF PLASMA HOMOCYSTEINE LEVEL AMONG SUDANESE PREGNANT LADIES
Rawya Alfatih Abd Almotalib Osman and Dr. Ibrahim Khider Ibrahim*
ABSTRACT
Background: There is many changes during pregnancy from first to third trimester if not following carefully may
have an adverse effect both mother and baby life, one of these varibles is homocysteine amino acid (Hcy) this
amino acid is methylated by MTHFR enzyme and B12 and folate as co-factor to give methionine which is
important in DNA formation. During pregnancy methionine may be actively transported to the developing embryo
that may decrease homocysteine in maternal plasma. Objectives: The aim of this study is to measure the plasma
homocysteine level among sudanese pregnant ladies and to correlate homocysteine level with lady clinical data
and age. Material and methods: A cross sectional study was performed in Khartoum state, sudan. A total of 30
EDTA blood sample collected from normal pregnant ladies in first trimester were included in this study, their age
is ranged between 18 and 38 years, plasma homocysteine level was masuread by immune assay ELISA. The data
were compared by using statistical analysis performed with statistical package for social sciences (SPSS) version
11.5 by using one sample T test. Result: The study showed that the mean of plasma homocysteine level in
pregnant ladies at first trimester by micromoles per liter is (4.093) which was significantly lowered compared to
normal range 5-14μmol/L (P-value0.00). Conclusion: Plasma homocysteine level is decreased during first
trimester of gestation.
Keywords: Hcy, pregnancy, plasma homocysteine, first trimester, MTHFR, B12, Folate.
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