EFFECT OF PHYLLANTUS AMARUS LEAF EXTRACT ON THE SERUM LIVER ENZYMES OF ALLOXAN-INDUCED DIABETIC ALBINO WISTAR RATS IN COLLEGE OF HEALTH SCIENCES AND TECHNOLOGY, NNAMDI AZIKIWE UNIVERSITY, NNEWI CAMPUS, ANAMBRA STATE, NIGERIA.
Ezeugwunne I. P.*, Umeaka B. K., Ogbodo E. C., Okpogba A. N., Analike R. A., Okwara J. E., Onyegbule O. A.4 and Okwara E. C.
ABSTRACT
This study was designed to investigate the effect of Phyllantus amarus (PA) leaf extract on serum liver enzymes activity in alloxan induced diabetic albino wistar rats. A total of 30 albino wistar rats each weighing 100g were assembled and divided into 3 groups (A-C) consisting of 10 rats. Group A received PA treatment, B was without PA treatment while group C served as the control group. 400mg/kg of aqueous extract of PA leaf was administered orally to the rats in group A but not in group B while group C received only water for 7 days. Blood samples were collected into plain containers for estimation of biochemical parameters (ALT, AST and ALP) respectively. Serum ALP, ALT and AST were analyzed using standard methods. There was a significant decrease in the mean serum activities of ALP (72.20±2.57 vs 94.90±9.34; p=0.000) and AST (36.10±2.60 vs 40.40±3.24; p=0.004) after PA administration whereas, ALT did not differ significantly (p>0.05). Again, the result shows a significant decrease in the mean weight of the subjects after PA administration (98.80±1.03 s 119.40±1.17; p= 0.000). This study revealed the hepatoprotective effect of PA use. Therefore, PA use could be of importance in prevention and management of liver diseases.
Keywords: Phyllantus amarus, Alanine aminotransferase, Aspartate aminotransferase, Alkaline Phosphatase, Weight, Liver Disease, Albino Wistar Rats.
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