JOBELYN ATTENUATES NEURONAL DEGENERATION IN CEREBELLAR CORTEX OF ADOLESCENT RAT EXPOSED TO BINGE ALCOHOL
Dr. Robert F. O* and Oyinbo C. A.
ABSTRACT
Cerebellar neurodegeneration is associated with chronic alcohol abuse. There is no clinically potent drug for alcohol-induced neurodegeneration. Though, it was hypothesised that multimodal neuroprotective agent presented outstanding therapeutic potentials in the management of CNS degeneration, however, the knowledge of what could constitute an effective and safe multimodal agent is not clear-cut. However, medicinal botanicals are naturally multimodal in their mechanism of action. The objective of this study is to assess the effect of Jobelyn supplement in a binge alcohol-induced neurodegeneration of the cerebellar cortex in adolescent rats. Two groups of adolescent rats were binge fed with either alcohol (25% w/v) or alcohol (25% w/v) and Jobelyn supplement in diluted nutritionally complete diet, 8 hourly for four consecutive days. The control animals received isocaloric non-alcoholic diet for equivalent days. The cerebellar cortices of animals in each group were evaluated histopathologically for degenerative changes. The extent of oxidative damage in the cerebellar cortex was assessed by tissue malondialdehyde (MDA), and advanced oxidation protein products (AOPP), concentrations. Results indicated that repetitive ethanol intoxication caused neuronal degeneration and oxidative damage in the cerebellar cortex. Jobelyn supplementation in alcohol-exposed rat significantly lowered the extent of neurodegeneration and oxidative damage. It was opined that the neuroprotective action of Jobelyn in alcohol-induced cerebellar neurodegeneration in adolescent rats is possibly through reductions of oxidative stress and neuronal degeneration.
Keywords: Alcoholism, cerebellum, medicinal plant, nutraceuticals, neuroprotection.
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