European Journal of Biomedical and Pharmaceutical Sciences

PREVALENCE OF DYSLIPIDEMIC HYPERTENSION IN A SUBSET OF KASHMIRI (NORTH INDIA) POPULATION

Rafiqa Eachkoti* and Hakim Ali Qanoon

ABSTRACT

Worldwide studies conducted on different populations have suggested a positive association between dyslipidemia and hypertension, with significant proportion of populations suffering from both ie dyslipidemic hypertension, most often possible mechanism being insulin resistance and endothelial dysfunctioning. The present study aimed to determine prevalence of dyslipidemic hypertension and to establish, if any, relationship between blood pressure and serum lipid levels across the range of blood pressure categories including prehypertension in a subset of Kashmiri population. A total of 100 patients and 50 control subjects from Kashmiri population were included in the present study. The level of TG and total cholesterol, LDL, HDL and VLDL in serum samples was estimated by enzymatic colorometric method on Hitachi 912 (Boehringer Mannhum system). Statistical analysis was carried out by students “t” test using ANOVA software and the results were considered statistically significance when p value ≤0.05. In our study overall 14.4% of total kashmiri population (i.e.72% of hypertensive kashmiri population) suffer from dyslipidemic hypertension. Significantly elevated total levels of serum TG (204.9mg/dl Vs 139.2mg/dl (p=000), total Cholesterol (175.1mg/dl Vs 147.2 mg/dl) (p=0.002), VLDL-cholesterol (41.0mg/dl Vs 28.9mg/dl) (p≤0.0001) LDL-cholesterol (181.3 mg/dl Vs 130.0 mg/dl) (p≤0.0001) and decreased level of HDL-cholesterol (34.8mg/dl Vs 46.1 mg/dl) (p≤0.0001) were found in hypertensive’s when compared with normotensive’s. Within lipid profile, greater percentage of hypertensive’s compared to normotensives show elevated levels of TG (51% Vs 18%) followed by cholesterol (49%\ Vs 21%) or LDL cholesterol(45% Vs 22%). Low HDL was also found in 44% of hypertensives compared to only 12% in normotensive’s. The findings of the present study show slight variations when compared with rest of the India but is in complete agreement with certain Muslim dominant areas with which we share common dietary habits and cultural practices. Conclusion: Our study reveals a positive association between blood pressure and dyslipidemia in Kashmiri population.72% of the hypertensive in our population shows dyslipidemia too. Since the treatment of dyslipidemia and hypertension alone is different from the treatment of dyslipidemic hypertension which may involve reversal of insulin resistance. The findings of the present study, therefore, may provide a rationale for pharmacotherapy in a subset of hypertensive people with dyslipidemic hypertension.

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