A COMPREHENSIVE REVIEW ON NOVEL DRUG DELIVERY VIA UNIQUE PROPERTY OF LIPOSOME
Preeti Pal, Kriti Pateriya and Pavan Kumar Yadav*
ABSTRACT
Liposomes (blister) are polymeric nanoparticles used for drug delivery due to their unique properties. Liposomes can encapsulate both hydrophobic (water hating) and hydrophilic drug (water loving). Liposomes deliver the drugs into cells by fusion or endocytosis mechanisms. In the last few decades, liposomes have been considered as ideal models for mimic biological membranes and also they are suitable carriers for drugs, diagnostics, vaccines, and other bioactive agents.Among several talented new / Novel delivery systems, liposomes characterize an novel technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipidcomposition, size, and charge of the vesicle. Various aspects related to mechanism of liposome formation, characterization and stability of the liposomal drug product were alsodiscussed in the article. Liposomes can be used as a therapeutic tool in the fields like tumor targeting, genetic transfer, immune modulation, skinand topical therapy.
Keywords: Liposomes, Drug Delivery, Nanoparticles.
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