AN OVERVIEW ON ADVANCE VESICLES FORMULATION AS A DRUG CARRIER FOR N.D.D.S
Santosh Kumar and Harikesh Maurya*
ABSTRACT
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery, diagnostics, nutraceuticals and biomedical for implants and prosthesis. The advance in nanotechnology helps in preparing newer formulations. One of the advancement in nanotechnology is the preparation of Proniosomes-derived niosomes. Provesicular systems, such as proniosomes which is one of the advancement in nanotechnology minimize problems of vesicular systems such as aggregation, fusion and leakage of drug and provide additional convenience in transportation, distribution, storage and dosing. Conventional vesicular systems such as liposomes and niosomes are particulate in nature and face stability related difficulty. This review article provides an insight about these approaches along with a novel vesicular approach known as proniosomes. Proniosomes is dry formulation using suitable carrier coated with non ionic surfactants and can be converted into niosomes immediately by hydration before administration. These proniosome-derived niosomes could equivalent or even superior than conventional niosomes. The drug carrier have been used in vesicle drug delivery system are Nanoparticles, Liposomes, Microspheres, Niosomes, Pronisomes, Ethosomes, Proliposomes.
Keywords: Proniosomes, Niosomes, Vesicle drug delivery system, Convenience in transportation and Nanotechnology.
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