European Journal of Biomedical and Pharmaceutical Sciences

PROTECTIVE ROLE OF RED GRAPE EXTRACT AND RED GRAPE LEAF EXTRACT ON NICOTINE IN MALE ALBINO RAT

K. Chennaiah*, M. Vani, P. S. Poornima, S. Kishore, K. Khalindar Basha, B. Vijayudu,
M. Venkatramudu, G. Ravi, P. Nagaraju and K. Sathyavelu Reddy

ABSTRACT

Cigarette smoking (Nicotiana Tabacum. L) is also a risk factor for respiratory tract and other infections, osteoporosis, reproductive disorders, adverse postoperative events and delayed wound healing, duodenal and gastric ulcers and diabetes. Consumption of Red grape and leaf flavonoids has been shown to confer antioxidant protection. In the present study Oxidative and poly enzymes has been assessed in nicotine administered rats to examine the effects of nicotine on the Oxidative enzymes defense systems in lung of male albino rat. Age matched rats were divided into 5 groups of six in each group and treated as follows: i) Normal Control (NC), ii) Nicotine treated (Nt), iii) Nicotine treated + Red Grape Extract treated (Nt+RGEt), iv) Nicotine treated + Red Grape Leaf extract (Nt+RGLEt) and v) Nicotine + Red Grape extract + Red Grape Leaf extract (Nt+RGEt+RGLEt). The enzymes such as Malondialdehyde (MDA), Xanthine oxidase (XOD), Uric acid were significantly decreased in nicotine treated rats in heart tisssue and increase was observed in the combination treatment (Nt+RGEt). This study suggests that improve of red grape extract and leaf extract treatment may be beneficial for nicotine intoxications.

Keywords: Nicotine, Red Grape Extract, Red grape Leaf Extract, Malondialdehyde (MDA), Xanthine oxidase (XOD), Uric acid, Lung tissue and Male albino rats.