European Journal of Biomedical and Pharmaceutical Sciences

A PROSPECTIVE OBSERVATIONAL STUDY AND DRUG USE EVALUATION IN POST- OPERATIVE PATIENTS WITH ANALGESICS AND ANTIBIOTICS USED IN SURGICAL WARDS OF A TERTIARY CARE HOSPITAL

*Dr. Kanamala Arun Chand Roby, Kotte Samanth, Bandi Shashi and Kaitha Sankarsh Reddy

ABSTRACT

Drug Use Evaluation is a method that focuses on improving and evaluating medication use processes with goal of improving outcome of patient. Most of the Drug Related Problems such as Adverse Drug reactions, Drug noncompliance can be prevented by Drug Use Evaluation Program. To Evaluate the Drug use evaluation of Analgesics and Antibiotics used in surgical wards of tertiary Care Center. Materials and methods: Study design: - Our study was hospital based prospective observational study conducted in a tertiary care hospital. Study population: - The study was done in the department of surgical wards. Study procedure: - The study was done by collecting information by using patient case sheets, based on the data a questionnaire prepared. Nearly data of 3600 patients were collect which include case history, demographic details and reason for admission, PMH, laboratory parameter and drug dose regimen with frequency were collected. Sampling method: - All the patient of age below 21-52 who is using analysis and antibiotic, who are willing to give consent, was included in the study. The surgical wards were visited four days in a week and information was called for the study and analyzed. Study duration: - The duration of the study was 9 months from Nov 2016 to July 2017. Results: A total of 360 patients who had undergone surgery were admitted in the surgical wards. Out of which 207 males and 153 females, the most frequent affected age group was 21 to 52. In this 54% were married and remaining are students. Out of this all patients received antibiotics and analgesics as well. The prescriptions are irrational due to the treatment is giving in multiple times for pain. So many interactions are identified during study with analgesics and antibiotics prescribed. Discussion: Out of 360 patients were of age group between 21 to 52, the most of the people admitted were males 207(57.50%) and females(42.70%), the most affected age group is 18 to 52, out of 360 patients married were 57.50% and unmarried were 42.70%, the educational level of the patients were secondary 162 (45%) and nutritional levels are below poverty all are poor 162(45%), the analgesics prescribed were diclofenac 153(42.50%), tramadol 153 (42.50%), aceclofenac 108(36%) and least analgesics prescribed were paracetmol 20% and antibiotics were cefatrixone 207 (57.5%), cefpodoxime 162(45%) and the least antibiotic was Gentamycin and the reason for admission was mainly due to orthopedic surgery and trauma, the maximum number of antibiotics and analgesics prescribed per day are 1 and for serious conditions its is prescribed up to 4 with clear monitoring, to overcome the gastric irritations proton pump inhibitors are prescribed. The patients have not have effective in treatment and maximum patients felt as average. The side effects of the drugs are observed and it’s mainly of constipation no serious side effects are observed and the drugs evaluation by the physician and advices are very much less and physicians are also not available all the time. Conclusions: Our study concluded that most of the surgeries are due to accidents or injuries during work. So, there is a great need for the adoption of various strategies to prevent/Minimize the inappropriate use of antibiotics and analgesics in order to improve the Quality of Medicines as much to reduce the number of significant interactions. By the guidance of clinical pharmacist we can reduce the interactions and also enhances the better outcome of patient.

Keywords: Diclofenac, tramadol, aceclofenac.