TANNINS OF JATROPHA GOSSYPIFOLIA EXERT ANTI-HYPERLIPIDEMIC EFFECT IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETIC RATS
Praveen Kumar Issac, Arun Jayaseelan, Sri Snehaa Chandrakumar and Sujatha Sundaresan*
ABSTRACT
Plants have assisted humankind since centuries as they are stockpiles of essential therapeutics and help to treat
chronic diseases. The main purpose of the study is to evaluate the anti-diabetic and anti-hyperlipidemic activity of
isolated tannins from methanolic extract of Jatropha gossipyfolia. A total of 30 male wistar rats aged 2 to 3
months and weighing about 180-200 g were divided into six groups. Type II diabetes was induced by single
intraperitoneal injection of 110 mg/kg b.w. nicotinamide and 50 mg/kg b.w. streptozotocin. Rats with marked
hyperglycemia of fasting blood glucose level ≥ 250 mg/dL were selected for the study. Experimental animals were
administrated with 25 and 50 mg/kg b.w. of tannins. Bio chemical parameters such as creatinine level, triglyceride
(TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density
lipoprotein (VLDL) and liver function parameters such as Glutamate oxaloacetate transaminase (GOT), Glutamate
pyruvate transaminase (GPT) were analysed. After sacrification of animals, the liver was collected and subjected
to histopathology analysis. Liver glycogen content was estimated spectrophotometrically. The experimental rats
treated with 25 and 50 mg/kg b.w. of tannins showed significant increase in HDL level and liver glycogen content.
The tannin treated rats exhibited a decrement in creatinine, TG, TC, VLDL, GOT and GPT levels. The isolated
tannins from methanolic extract of Jatropha gossipyfolia possesses anti-diabetic and anti-hyperlipidemic activity
in streptozotocin-nicotinamide (STZ-NIC) induced diabetic rats.
Keywords: Jatropha gossipyfolia, Tannins, STZ-NIC induction, Biochemical parameters, Glycogen content, Anti-hyperlipidemic activity.
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