DIPEPTIDYL PEPTIDASE-IV INHIBITION AND EX-VIVO ANTIOXIDANT POTENTIAL OF PHYTOCOMPOUNDS OF WITHANIA SOMNIFERA, TRIGONELLA FOENUM AND BAUHINIA PURPUREA
Anand-Krishna Singh and Heera Ram*
ABSTRACT
Indigenous medicinal plants possess peculiar kinds of phytocompounds uses for various kinds of ailments as well
as particularly remedy for diabetes by local people through utilizing traditional knowledge and are source of new
drugs discovery. Photochemical have been found to possess a wide range of activates which may help in
protection against chronic disease. The efficiency of certain antidiabetic plants contains some bioactive
compounds of natural derive could be, at least moderately, explained by the inhibition of DPP-IV. In the present
study, we were isolate and quantified some of the phytocompounds such as alkaloid, flavonoids, phenolic and
phytosteroids etc, act as DPP-IV inhibitors, which is a novel potential for the treatment of type 2 diabetes mellitus;
we isolated the different bioactive fractions from Withania somnifera, Trigonella foenum, Bauhinia purpurea were
investigated for their potential to serve as a natural source of DPP-IV inhibitors. Methanolic extract (1 mg/ml) of
W. somnifera inhibited DPP-IV activities (76.3±1.45%) at greater extent than that of T. foenum (65.6±0.98%) and
B. purpurea (63.5±0.78%) as compared to standard drug i.e. sitagliptin (96.3±1.26%). W. somnifera and B.
purpurea extract was reported to inhibit DPPH free radicals and inhibited erythrocytes haemolysis in higher than
the T. foenum. The result of present study ravel that W. somnifera, T. foenum and B. purpurea plant extracts
possess some novel DPP-IV inhibitors like phytocompounds and can be developed as therapeutic molecules for
type 2 diabetes mellitus. The result of present study reveal that extracts of WS and TFG contains novel DPP-IV
inhibitors with antiperoxidative potential and can be developed as therapeutic molecules for type 2 diabetes
Keywords: Dipeptidyl Peptidase-IV inhibition, Erythrocytes hemolysis, Phytocompounds, Antioxidant, Type 2 diabetes mellitus.
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