Abstract
CORRELATION OF IMMUNOHISTOCHEMICAL EXPRESSION OF VITAMIN D RECEPTOR (VDR) AND PROGESTERONE RECEPTOR (PR) IN INVASIVE DUCTAL CARCINOMA TISSUES

*Fasogbon Samuel Ayobami, Okorie Nnaemeka, Abubakar Usman, Zakariya A. A., Umar Saratu and Imam Aisha Babakura

ABSTRACT

Aim: The study was carried out to determine the Immunohistochemical Correlation between the Expression of Vitamin D Receptor (VDR) and Progesterone Receptor (PR) in Invasive Ductal Carcinoma (IDC) tissues. Materials and Method: A total number of fifty six (56) archived female breast Invasive Ductal Carcinoma tissue blocks were used. The tissue blocks were sectioned at not more than 2μm each. Haematoxylin and Eosin staining method and immunohistochemical staining technique using VDR and PR antibodies were done and the results were correlated. Result and Discussion: The results show that there is a significant difference (P<0.05) found comparing the imunohistochemical expression of VDR with PR in IDC tissues. Conclusion: VDR antibody cannot be use in replacement of PR antibody in the immunohistochemical diagnosis of Invasive ductal carcinoma (IDC) of the breast.

Keywords: Vitamin D receptor (VDR), Progesterone receptor (PR), Invasive ductal carcinoma (IDC), Breast Cancer.


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