European Journal of Biomedical and Pharmaceutical Sciences

NEW 2H-CHROMENE-3-CARBOXAMIDE DERIVATIVES: SYNTHESIS AND EVALUATION OF ANTIDEPRESSANT ACTIVITY

Komal Ashok Rajgire*, Ankit Laxman Tupsundar, Rutuja Prabhakar Sonare and Dr. Ashok Pandurang Pingle

ABSTRACT

A series new (Coumarin) 2H-chromene-3-carboxamide derivatives 5a-5g are were synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors and they all are evaluate for the antidepressant activity by using animal model for antidepressant i.e. Force Swim Test (FST) and Tail Suspension Test (TST) on mice the immobility time is recorded for 6 min (360sec) after the treatment with the test compound given to mice by i.p. rout of drug administration, and reference standard used for this test is Fluoxetine the reading is note down after 1hr, 5hr and 24 hr. The result is plotted by using the Mean ± SEM of the group of animal used for the animal activity. The synthesized compound 5b shows the less Immobility time than 5a and immobility time is slightly more than the standard drug Fluoxetine.

Keywords: Coumarin, MAO-A, MAO-B, Antidepressant, Force Swim Test, Tail Suspension Test, Fluoxetine.