ASSESSMENT OF TRACE ELEMENTS IN SUDANESE PREECLAMPTIC PREGNANT WOMEN
Elhashimi E. Hassan*, Wiaam Sir Elhhatim, Siham M.Bakhit, NassrEldin.A.Shrif,Mohammed A.Huneif
ABSTRACT
Background: Preeclampsia is a common gestational disorder which
complicates 5-8% of pregnancies and it is associated with maternal,
fetal and neonatal morbidity and mortality. Minerals have important
influence on the health of pregnant women and growing fetus and their
Alterations in serum have been suggested as effective factors in
causing preeclampsia. Objectives: This study was aimed to assess the
serum trace elements; zinc, copper and magnesium levels in
preeclamptic and normal pregnant women. Methods: Hospital-based
matched case control study was conducted during the period from October 2013 to April
2014. Cases were One hundred twenty two preeclampatic women and controls were 79
apparently health pregnant women from the Khartoum Teaching Hospital and Omdurman
maternally hospital in Khartoum state, Sudan. Blood specimens were collected from both
groups and serum levels of Zn, Cu and Mg were estimated using atomic absorption
spectrophotometer. The characteristic base line data were collected using structural
questionnaire. Processing and analysis of data was carried out by means of statistical package
for social science (SPSS version 16). Results: The means of serum trace elements zinc,
copper magnesium levels in pregnant women with preeclampsia were significant lower
(49.4 ± 17.0), copper (47.9 ± 20.0) and (1.23 ± 0.38) compared to (90.3 ± 16.8) , (91.7 ±
23.2) and (2.04± 0.22) in healthy pregnant women , respectively. The trace elements zinc, copper & magnesium levels were found to be significantly decreased in pregnant women
with preeclampsia. The maternal mean serum level of Zinc, Cu and Mg were lower among
the severe PE patients compared to the mild patients (P.value < 0.05). There was no
correlation between Age, parity and gestational age and serum level of zinc, copper and
magnesium in mild and severe preeclamptic women (p. value <0.05). Conclusion: This study
established that the levels of zinc, copper and magnesium were significantly altered in
pregnant women with pre-eclampsia supporting the hypothesis on the role of magnesium
copper and zinc deficiency in preeclampsia pathophysiology .
Keywords: Zinc, Copper, Magnesium & Pre-eclampsia.
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