Abstract
A FLOURESCENCE QUENCHING BASED METHOD FOR THE DETERMINATION OF RISPERIDONE IN BULK AND TABLETS

Khalid A.M. Attia, Ahmad A. Mohamad and Mohamed S. Emara*

ABSTRACT

Objective: The objective of the method was to develop a new, simple, rapid and accurate spectrofluorimetric method for the determination of risperidone in bulk and tablets. Method: Quenchofluorimetric method; is based on the study of quantitative quenching effect of risperidone on native fluorescence of eosin-y in acidic medium due to the formation of ionpair complex. The fluorescence intensity was measured at 555 nm after excitation at 260 nm. Results: Under the optimum conditions, the quenched fluorescence intensity was linear with the concentration of risperidone in the range of 0.5 – 7 μg/ml (R2= 0.9998) with a detection limit of 0.015 μg/ml. The proposed method was successfully applied to the analysis of risperidone in pure form and tablets with good precision and accuracy compared to the reported method as revealed by t- and F- tests. Conclusion: The developed method was simple, fast, sensitive, accurate and precise. It is the first time to develop spectrofluorimetric method for determination of risperidone in bulk and tablets. It could be applied for routine quality control analysis of risperidone in its pure form and in tablets.

Keywords: Fluorescence quenching; risperidone; spectrofluorimetric method.


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