Abstract
ROLE OF RED GRAPE EXTRACT AND NICOTINE ON ENERGY METABOLISM WITH REFERENCE TO AGING

M. Subahan, K. Khalindar Basha, K. Chennaiah*, M. Vani, P. S. Poornima, M. Venkatramudu and
K. Sathyavelu Reddy

ABSTRACT

In the present study energy metabolism has been assessed in nicotine administered rats to examine the effects of nicotine on the energy metabolism defense systems in heart of male albino rat. Age matched rats were be divided into 4 groups of six in each group and treated as follows: Group I, Normal Control (NC) (Control rats received 0.9% saline). Group II, Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months). Group III, Red grape extract treated (RGEt). (Red grape extract at a doses of 25 mg/ kg body weight via orogastric tube for a period of 2 months). Group IV. Nicotine + Red grape extract treated (Nt+RGEt) (The forth group of rats were received the nicotine + red grape extract as followed by the second and third group). The energy metabolism profiles such as Mg2+- ATPas, Ca2+ – ATPase, Creatine phosphokinase (CPK) were significantly decreased in nicotine treated rats in heart tisssue and increase was observed in the combination treatment (Nt+RGEt), This study suggests that red grape extract treatment may be beneficial for nicotine intoxications.

Keywords: Nicotine, Red Grape Extract, Mg2+-ATPas, Ca2+–ATPase, Creatine phosphokinase (CPK), Heart and Male albino rats.


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