European Journal of Biomedical and Pharmaceutical Sciences

SOLUBILITY ENHANCEMENT OF ETODOLAC BY SOLID DISPERSION TECHNIQUES

Devidas Gulabrao Bachhav* and Somashekhar S. Khadabadi

ABSTRACT

The aim of the present study was solubility and dissolution rate enhancement of etodolac by using different solid dispersion techniques. Solid dispersion of etodolac was prepared by kneading and solvent evaporation method. Solid dispersions of etodolac with PEG-600 and guar gum were prepared in different ratios as 1:1, 1:2, 1:3. FTIR, DSC and XRD were performed to study the interaction between drug and polymers. In solid dispersion formulations there was decrease in crystallinity of etodolac, which leads to increase in dissolution of etodolac from solid dispersions. All methods showed improvement in dissolution profile of etodolac as compare to pure drug. Solvent evaporation shows faster drug release as compared to physical mixture and kneading method (etodolac and guar gum) this might be due to the hydrophilic nature of the carrier, hydrodynamic microenvironment was changes and drug get dispersed in to polymer which prevents aggregation and/or reagglomeration phenomenon during dissolution. At time of dissolution, drug and carrier from mixtures comes in contact with dissolution fluid, passing of dissolution medium into drug carrier particles takes place, which initiates the formation of stagnant gel layer of carrier around the particles. The drug particles that are separate entities but disperse rapidly throughout dissolution medium and expose a greater surface area, resulting in rapid drug release.

Keywords: Solubility enhancement, solid dispersion, kneading, solvent evaporation.