A STUDY OF SERUM ADA ISOENZYMES AND MDA LEVELS IN TUBERCULOSIS WITH TYPE II DIABETES MELLITUS
Dr. A. Sangeetha and Dr. Murugan G.*
ABSTRACT
Tuberculosis and Type II diabetes mellitus are a major cause of morbidity and mortality in India. Diagnosis of
sputum negative tuberculosis has been a challenge to the clinicians and search for reliable markers for early
diagnosis has been an ongoing effort. Type II diabetes mellitus has also been diagnosed most often accidentally
during routine checkup or during investigation of other disorders. Serum adenosine deaminase(ADA) levels have
shown promising results as a marker for diagnosis of sputum negative TB. Serum ADA levels have also been
reported to be elevated in Type II diabetes mellitus. ADA exist as two isoforms ADA1 & ADA2. The isoenzyme
pattern of the elevated serum ADA is not known. Both tuberculosis & Type II diabetes mellitus are associated
with increased lipid peroxidation(MDA). Aim & Objectives: The present study was conducted to study the
relevance of serum ADA and MDA levels in Tuberculosis and Type II diabetes mellitus patients. Materials and
Methods: Our study includes 20 normal subjects came for routine health check up in our institution and 20
patients each between ages of 20-70 years with confirmed diagnosis of TB and Type II diabetes mellitus in South
indian population. Results: The serum ADA isoenzyme fractions and MDA levels were significantly increased in
both Tuberculosis patients and Type II diabetes mellitus patients compared to control groups. Conclusion: Serum
ADA as well as its isoenzyme levels are significantly elevated in patients with tuberculosis and Type II diabetes
mellitus compared to normal controls. Oxidative damage reflected as MDA levels is positively correlated with the
extent of ADA elevation in tuberculosis and Type II diabetes mellitus patients.
Keywords: ADA isoenzymes, Tuberculosis, Type II Diabetes Mellitus, south indian population.
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