European Journal of Biomedical and Pharmaceutical Sciences

ACUTE ORAL TOXICITY STUDY OF THE SIDDHA MEDICINE GOWTHAMAR CHOORANAM IN WISTAR ALBINO RATS

D. Prakash*, G. Anitha, V. Vel Pandian, N. J. Muthu Kumar and V. Banumathi

ABSTRACT

Gowthamarchooranam is one of the poly herbal medicine in siddha system in the treatment of jaundice and respiratory diseases. The preparation was taken from The Pharmacopoiea of siddha research medicines.[1] The study was conducted as per the guidelines of Organization for Economic Cooperation and Development. The experimental protocol was approved by the institutional ethical committee (IAEC) under CPCSEA (approval no: KKCP/2014/020/CPCSEA). It is the principle of the test that based on a series of procedure with the use of a minimum number of animals per step; sufficient information is obtained on the acute toxicity of the test substance to enable its classification. The substance is given orally to a group of experimental animals at one of the defined doses. No mortality was observed in Gowthamar Chooranam during this acute oral toxicity study at the dose level of 5mg, 50mg, 300mg and 2000mg. Hence we can conclude that the drug is safe for clinical use.

Keywords: Acute oral toxicity, Gowthamarchooranam, OECD, Toxicity, Herbal.