Abstract
SYNTHESIS, CHARACTERIZATION AND ANTI OXIDANT ACTIVITY OF NOVEL 1,5 BENZOTHIAZEPINES FROM CHALCONES OF 1-(2,4-DIFLUOROPHENYL) ETHANONE PRECURSOR

P. S. Raghu*

ABSTRACT

1,5 benzothaizepines heterocyclic ring system having the diverse pharmacological activities. The present work focus on synthesis of novel benzothaizepines molecules by condensation of 1-(2',4'-difluorophenyl)-3-(4"- methylphenyl)-2-propen-1-one derivatives and O-amino thiophenol in the presence piperidine and glacial acetic acid. The structures of compounds were confirmed by spectral analysis using IR, 1HNMR and Mass analysis. The biological evolution of compounds were performed for anti oxidant activity by using DPPH reagent method using standard ascorbic acid.

Keywords: Chalcones, 1,5 benzothiazepines, DPPH reagent, anti oxidant activity.


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