Abstract
SYNTHESIS OF 2-HETRYLAMINO SUBSTITUTED ANALOGUES OF THE FACE ‘D’ PYRIDO CONDENSED BENZAZEPINES OF MEDICINAL INTEREST

*Aditi and Rajendra Singh

ABSTRACT

It has been observed that the incorporation of the bioactive pharmacophores such as pyrrolidine, piperidine, piperazines etc. in the existing drug molecules, exert a profound influence on the biological profiles of the parent molecules. Greatly encouraged by such a trend in the literature,it was planned in the present communication to incorporate in 6, the structural features of pyrrolidine,piperidine,N-substituted piperazines (N-methyl, N-ethyl, N-benzyl, N-carboxyethyl, and N-acetylpiperazines) to afford the compounds 6.030-6.037 [Scheme-2] respectively, following the procedures described for their incorporation, other related substrates in the literature.[1-3]

Keywords: 10-fluoro-4-(methylamino)-6-(methylthio)-2-phenyl-5H-benzo[b]pyrido[2,3-d]azepin-1-oxide.


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