European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF BENZIMIDAZOLE DERIVATIVES

Asma Eswayah*, Rima Hermas, Souad Khaliel, Rehab R. Walli, Amal Belaid, Omran Fhid, Marwa Elmelady, Esraa Elhaddad, Fadilah Aleanizy and Fulwah Alqahtani

ABSTRACT

A series of benzimidazole derivatives having imine linkage were synthesized by using o-phenylenediamine as starting material. In first step, o-phenylenediamine is treated with 4-amino benzoic acid to give 2-(4-aminophenyl) benzimidazole (1a) which was then treated with different substituted aldehydes to give benzimidazole containing Schiff bases (1-12). All the synthesized compounds have been characterized by physical and spectral analysis, and their antimicrobial activity was investigated by agar-well diffusion method. Only compound 11 have shown antibacterial activity against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae, while compounds 10 and 11 showed antifungal activity against Candida albicans. The minimal inhibitory concentration (MIC) for compounds 10 and 11 was determined by broth microdilution method. The other compounds were found to exhibit no activity against the bacterial and fungal organism tested.

Keywords: 2-Substituted Benzimidazole, Schiff Base, Antibacterial Activity, Antifungal Activity.