European Journal of Biomedical and Pharmaceutical Sciences

RESISTANT PATTERN OF NALIDIXIC ACID AGAINST UROPATHOGENS IN SELECTED AREAS OF DHAKA CITY, BANGLADESH

Mohammad Asaduzzaman*, Apu Alam Miah, Md. Khairul Alam Bhuiyan, Md. Jahangir Alam, Farha Matin Juliana, Nazmul Hossain, Biswajit Das and Runa Asma

ABSTRACT

Treatment of urinary tract infections is becoming more complicated with an increase of the number of resistant strains to antibiotics and prevalence of antibiotic resistance mechanisms. Our aim was to assess the susceptible pattern of Nalidixic Acid which is a synthetic drug of Quinolone antibiotic against uropathogens which cased Urinary Tract Infections. A total of 9178 urine samples were collected in 2016 (January-December) and out of which 890 (9.70%) were bacteriologically positive. Among the isolated uropathogens, 94.1% were gram negative and 5.9% gram positive organism. Male were found more prone to get UTI under 10 years and between 51-80 years of age and females were more affected in 10 to 50 years and over 80 years of age group. E. coli was the most prevalent (83.9%) isolate followed by Klebsiella spp. (7.1%), Staphylococcus aureus (3.1%), Enterococci spp. (2.6%), Pseudomonas spp. (2.2%), Proteus spp. (0.8%) and Staphylococcus saprophyticus (0.2%). The most predominant sensitive organisms to Nalidixic Acid were Klebsiella spp. (male 31.3% and female 40.4%) and resistant organisms Pseudomonas spp. (100%) and Proteus spp. (100%) in both male and female found. Around 87.6% male and 76.8% female were found resistant to E. coli.

Keywords: Nalidixic Acid, Quinolone, UTI, Resistance, Uropathogen.