Abirame S.*, V. Paheerathan V. and Pirathipkumar R.


This study was a comparative in vivo study, conducted in Wistar albino rats at Unit of Siddha Medicine, Trincomalee Campus, Eastern University of Sri Lanka. Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke and VTE Major burden of disease across low-income, middle-income and high-income countries. The plant Bambusa arundinacea was selected for this study. The plant Bambusa arundinacea belongs to the family Bambusaceae which popularly known as Bamboo in English and Mungil in Tamil and found throughout in India, Burma and Ceylon. In Ceylon it is common along river banks in the warmer parts of the island. It is a perennial tree with many stems tufted on a stout root stock; stems branching from the base, 24 —30 m high, 15—17.5 cm diameter, graceful, curving; nodes prominent (the lowest rooting), the lower emitting horizontal, almost naked shoots, armed at the nodes with 2 or 3 stout, recurved spines sometimes 2.5 cm long (Jayaweera, 2006). Adult female Wister albino rats of weighing around 200-250gm were obtained. The animals housed in cages under standard laboratory condition. The albino rats were divided into 2 groups 6 animals in each. Mean values of baseline bleeding time 84.50 ± 14.761sec in standard group and 88.50 ± 9.813 sec in test group after overnight fasting for 12 hours. After induced by intraperitoneal injection of the thromboplastin (#0203) - 0.48ml injection the mean values of bleeding time were subsequently decreased 69.50 ± 12.787 sec in standard group and 76.33± 9.688 sec in test group. Then the treatment was continued. Standard group administered with Phytomenadione (Vitamin K) and test group administered with Bambusa arundinacea leaves Powder (direction of medicine bid). After that rat’s tail bleeding time was noted at 0 min, 30min and 60min after 3h and 24h. Study was tested for (using assessment (Time-Dependence Pattern)) anti-thrombotic activity. Mean value results in Standard group (0 min: 76.50 ± 10.083s, 30 min: 74.20 ± 9.757s and 60 min: 75.80 ± 8.786s) after 3h. Mean value results in test group (0 min: 89.00 ± 6.831s, 30 min: 85.40 ± 10.526s and 60 min: 84.83 ± 11.250s) after 3h. Mean value results in Standard group (0 min: 77.00 ± 8.485s, 30 min: 81.80 ± 7.396s and 60 min: 89.33± 6.377s) after 24h. Mean value results in test group (0 min: 103.33 ± 13.619s, 30 min: 103.83 ± 13.586s and 60 min: 105.17 ± 13.977s) after 24h.P value of bleeding time in standard group [0min: (0.391), 30min: (0.142) and 60min :(0.049) after 3h treatment. P value of bleeding time in test group [0min: (0.001), 30min: (0.001) and 60min :(0.000)] after 3h treatment respectively. P value of bleeding time in standard group [0min: (0.012), 30min: (0.007)] and 60min :(0.007) after 3h treatment. P value of bleeding time in test group [0min: (0.000), 30min: (0.000) and 60min :(0.000)] after 24h treatment respectively. In comparison of bleeding time, both the standard and test groups indicate significance of bleeding time (P value less than 0.05). The significance of bleeding time higher in the test group in comparison to standard group. Hence antithrombotic activity of Bambusa arundinacea leaves powder is higher compared to Phytomenadione (Vitamin K). Bambusa arundinacea leaves possess source of antithrombotic activity compounds for the management of various thrombogenic disorders.

Keywords: Antithrombotic activity, Bambusa arundinacea, Phytomenadione (Vitamin K), Thrombosis, Thromboplastin, Bleeding time.

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