European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF NIOSOMES CONTAINING TAMOXIFEN

Naresh Kalra*, Dr. G. Jeyabalan and Suresh Choudhary

ABSTRACT

This study was aimed at developing and optimizing Niosomal formulation of Tamoxifen Citrate in order to improve its bioavailability. In evaluation study the effect of the varying composition of non ionic surfactant and cholesterol on the properties such as encapsulation efficiency, particle size and drug release were studied. In this drug delivery systems are defined as formulations aim for transportation of a drug to the desired area of action within the body. Niosomes were prepared by Ethanol injection method using cholesterol and Surfactant. Particle size, zeta potential, entrapment efficiency and In vitro drug release studies were performed. The targeted niosome delivery system is composed of drug, surfactant and cholesterol. With regard to the influence of formulation variables on the percent drug loading (PDL), different compositions with varying ratios of surfactant and cholesterol were studied. In Vitro drug release mechanism was studied for 24 hours. Different batches of Niosomes were prepared in order to select an optimized formula and proportion of surfactant and cholesterol for the preparations of Niosomes.

Keywords: Niosomes, Ethanol injection method, In-vitro release. Span 20.