Abstract
EVALUATION OF ANTI-DIABETIC ACTIVITY ON N-BUTANOL FRACTION OF LEAF METHANOLIC EXTRACT OF CURCULIGO ORCHIOIDES (AMARYLLIDACAE) IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Kanakam Vijayabhaskar*, Mahesh ArunaDevi, Perla Harikrishna, Bhukya Nageshwar Rao, Bairi Padma, Syed Saleem Ahemad

ABSTRACT

The aim of present study to evaluate anti-diabetic activity of methanolic extract n-butanol fraction of Curculigo orchioides(Amaryllidacae) against in streptozotocin induced diabetic rats. Fraction were administrated orally at 200 mg/kg and 100mg/kg for 3weeks. The effects was compared with oral dose of 10mg/kg of Glibenclamide. Blood glucose levels are determination by GOD-POD kit method. In the results, our study indicates that Curculigo orchioides n-butanol fraction of leaf methanolic extract exhibited significant anti- hyperglycemic activities in streptozotocin-induced hyperglycemic rats without significant change in body weight. And shows the Values are given in average body weight (g) ±SEM for groups of six animals each. a Normal saline. b Normal saline + streptozotocin. Significance vs. Control group *P<0.01. **P< 0.005, ***P<0.0001.

Keywords: Anti-diabetic activity, Curculigo orchioides methanolic extract, n-butanol, Streptozotocin, GOD-POD.


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