European Journal of Biomedical and Pharmaceutical Sciences

CHARACTERIZATION OF MUCOADHESIVE PROPERTIES OF pH RESPONSIVE MESOPHASES BASED ON MONOOLEIN AND OLEIC ACID

Prakash Rajak* and Lila Kanta Nath

ABSTRACT

Mucoadhesive systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability expand and improvement in both local and systemic effects. A group of fatty acid esters capable of forming liquid crystals has been identified as a new class of potential bioadhesive substances. Hexagonal and cubic mesophases are exceptionally of high curiosity in the mucoadhesive drug delivery area because of their excellent prospective as drug carrier. The experimental work was focused on the pH responsive monoolein (MO) and oleic acid (OA) mixture mesophases. The pH responsive mucoadhesive properties of MO and OA have been proven through a flushing in vitro experiment approach and a tensiometric approach using a TA.XT Plus texture analyzer. It has been proven that a combination of monoolein (MO) and oleic acid (OA) ready of self-assembling right into a cubic phase at pH 7.4 and switching into hexagonal phase at pH 1.2. The test methods showed evidently that MO/OA mixture mesophases possess pH responsive mucoadhesive properties. Furthermore we had shown the fact that cubic phase has brilliant mucoadhesive properties as compared to hexagonal phase and for that reason an exciting candidate for a bioadhesive drug delivery system.

Keywords: Mucoadhesive, Mesophase, Monoolein, Oleic acid, Liquid Crystal.