HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF METHONOLIC SEED EXTRACT OF EMBELIA ROBUSTA IN ALLOXAN INDUCED DYSLIPIDEMIA IN WISTAR RATS
Sharada Seekonda*, T. S. Usha Sree, K. Indira, G. Padmaja and A. Roja Rani
ABSTRACT
Ayurveda refers Embelia robusta (Sanskrit: Tandula) as a medicinal plant used for the treatment of diabetes mellitus, anticancer, antiinflammatory, antifungal, antibacterial. Objective: The present study was carried out to evaluate the hypolipidemic activity of methonolic seed extract of E.robusta in normal and Alloxan induced diabetic dyslipidemic rats. Method: Diabetes was induced in male wistar rats by single intraperitonial injection of Alloxan (130mg/kg) body weight. After diabetic induction methanolic seed extract of E.robusta at the dose 50mg/kg (T1) and 100mg/kg (T2) body weight was used as a test drug and Gliclazide 50mg/kg body weight as a standard drug to the diabetes induced experimental rats for 30days. Acute toxicity and Oral glucose tolerance study was carried out in normal rats, Activity of methonolic seed extract of E.robusta on lipid profile was carried on diabetes induced rats, which showed significant reduction in lipid parameters in both Test group T1 & Test group T2. Result: Acute toxicity study showed no signs of toxicity by methanolic seed extract of E.robusta even when the dose was increased to 4000mg/kg body weight. In oral glucose tolerance test rats treated with methanolic seed extract of E.robusta at the dose T2 showed significant (P<0.05) reduction in hyperglycaemic control in Group-IV and there was significant reduction in serum level TC (116.3), TG (108.7), LDL (36.43), VLDL (21.7) and increases in level of HDL (58.17), comparable to the standard control. Conclusion: The results indicate that methonolic seed extract of E.robusta has hypoglycemic and hypolipidemic activity.
Keywords: E. robusta, Alloxan, Acute toxicity, Oral glucose tolerance, Hypolipidemia.
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