Abstract
GREEN CHEMISTRY APPROACH SYNTHESIS, SPECTRAL AND BIOLOGICAL CHARACTERIZATIONS OF Cd(II) AND Hg(II) COMPLEXES WITH BIO-ACTIVE ISONIAZID AND BENZOATE ION

P. Manikandan*, K. Rajasekar, T. Gomadurai, B. Sathiyamoorthy and P. Sudhakar

ABSTRACT

Novel metal complexes of Cd(II) and Hg(II) with Isoniazid and Benzoate ion have been synthesized by microwave assisted method. The Synthesized complexes have been characterized by elemental analysis, metal estimation, molar conductance, cyclic voltammetry and spectral methods viz., UV-visible, IR, Far-IR and NMR. The elemental analysis and metal estimation of the complexes show that 1:1:2 ratio of composition of metal and each ligands. The molar conductance values indicate the non-electrolyte (1:0 types) of the complexes. The redox properties of the metal complexes were investigated by electrochemical method using cyclic voltammogram. The complexes exhibited quasi-reversible one electron transfer reaction. The tetrahedral geometry from UV spectra and the metal ions coordinate in a bidentate mode of Isoniazid and monodentate mode of benzoate ion from IR and metal linked atom from Far-IR spectral data were deduced. The 1H-NMR and 13C-NMR spectra of diamagnetic metal ions in complexes was carried out, the chemical shift indicating the mode of coordination of ligands to the metal ions. Moreover it is concluded that isoniazid acts as a bidentate ligand, coordinating through hydrazinic nitrogen and carbonyl oxygen. The biological activity of the ligand and its complexes were tested by the antibacterial strains of Actinobacter and Salmonella typhi, antifungal strains of Aspergillus Niger and Candida albicans. The biological activities confirm that these metal complexes are more potent than of the free ligand.

Keywords: Isoniazid, Benzoate ion, Cyclic voltammetry, Antibacterial, Antifungal, Metal complexes.


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