ISOLATION OF ANTI THIAMINE COMPOUND FROM THE LEAVES OF ABRUS PRECATORIUS LINNAEUS: EFFECT OF SEASON ON YIELD OF THE COMPOUND
Prasenjit Mitra, Tanaya Ghosh and Prasanta Kumar Mitra*
ABSTRACT
Abrus precatorius Linnaeus (A. precatorius L.), a medicinal plant popularly known as gunja, rosary pea, jequirity bean etc. has been used for therapeutic purpose since Vedic period. Recently we observed anti thiamine activity of A. precatorius L. leaves. Objective of the present work was to isolate the anti thiamine compound present in the plant leaves. As amount of secondary metabolite in plants varies with season, effect of season on yield of the anti thiamine compound was also studied. A. precatorius L leaves were collected in different seasons, identified by taxonomist, washed thoroughly, shade dried and powdered. Isolation of the anti thiamine compound from the powdered leaves was carried out maintaining principles of standard isolation procedures of chemical compounds from plant sources. A compound was isolated from A. precatorius L. leaves . 1 mg of the isolated compound could inactivate 24.9 μg of thiamine hydrochloride in 1 h in in vitro experiment. Yield of the anti thiamine compound was maximum during the months of May – June. Isolation of anti thiamine compound from A. precatorius L. leaves suitably compliments the anti thiamine activity of the plant leaves.
Keywords: Abrus Precatorius linnaeus leaves, anti thiamine activity, seasonal variation.
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