European Journal of Biomedical and Pharmaceutical Sciences

A STUDY ABOUT INCIDENCE OF DYSLIPIDAEMIA IN COMPARISON WITH PATIENTS ON ART AND NOT ON ART

Amudavalli K. and Amudhan Arvind E.*

ABSTRACT

Introduction: The extensive use of highly active antiretroviral therapy (HAART) which is highly effective in HIV patients has ended up with an high incidence of complications like HIV-associated lipodystrophy syndrome and the metabolic alterations, particularly lipid and glucose metabolism. Evidences in support of dyslipidaemia associated with First- line HAART in our geographical location is very minimal. The aim of the present study was to study and compare Lipid profile in HIV positive patients on ART with that of newly diagnosed HIV positive patients who were yet to be started on ART. Materials and Methods: Hundred newly diagnosed HIV positive patients who were yet to be started on ART were taken as controls. Similarly hundred randomly selected HIV+ patients who were already on ART regimen for more than 12 months were taken as cases. This study was conducted for a period of 12 months at the Government Dharmapuri Medical College, Dharmapuri. Results: There was a significant increase (p<0.001) in serum Total Cholesterol, LDL-C, TG, VLDL, Non-HDL -C & TC/HDL-C ratio in ART patients compared to ART-naïve patients. ART has an effect on lipid parameters in HIV patients. Conclusion: It is clear from our study that there is increase in lipid profilemin ART patients compared to ART Naïve group. Hence it appears reasonable to measure fasting lipid levels before and 3-6 months after antiretroviral therapy is initiated or when ART regimen is changed so that treatment for dyslipidemia may initiated at the earliest.

Keywords: Dyslipidaemia, ART, HIV.