Abstract
EVALUATION OF TRICHOLEPIS GLABERRIMA FOR ANALGESIC ACTIVITY USING IN VIVO MODELS

Veena Rani I.*, Syed Najamuddin Ali and Kiranmai G.

ABSTRACT

The main objective of present study was to evaluate the analgesic activitiy of the 95% w/v methanolic extract of Tricholepis glaberrima (METG) a plant used as traditional remedy and popularly known as “Bhramdandi” belongs to the family Asteraceae and was screened for various pharmacological activities. The analgesic effect was examined by two methods the Eddy’s Hot plate method and Tail immersion method at the doses of 100, 200,400 mg/kg. The results showed 200 and 400 mg/Kg of the extract were more significant and comparable with the effect of diclofenac sodium 30mg/kg. The results of this study demonstrated the analgesic effect of METG extract in animal models which showed that the latency period of METG extract was almost equal at 0 min and gradually increased from 60 min, peaking at 90 min and justified traditional use of this plant in the treatment of pain. More studies are needed to elucidate the active components.

Keywords: Tricholepis glaberrima (METG).


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