INVITRO PHARMACOGNOSTIC EVALUATION & ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA EXTRACT IN HEP G2 CELL LINES
Mathan Kumar S.* and Dr. Mohamed Salem Gani A.
ABSTRACT
Cancer (medically termed as malignant neoplasm) is a class of disease which affects any parts of the body, with a characteristic feature in common, meant the uncontrollable cell growth, which divide and grow uncontrollably forming tumor. Human liver cancer is the fifth most common, which is a serious pop of most developing countries. It is a sad fact that, majority of hepatocellular carcinoma dies within one year after diagnosis. At present the treatment of hepatocellular carcinoma includes surgery and chemotherapy, but the curative effect of chemotherapy is not good enough since with major side effects. Therefore peeping for high efficient antitumor drugs remains a hotspot in life science research. Herbs have been a richest source of therapeutic agent and still an important source of new drugs for diseases such as cancer. Certain plant components capable of killing cancer cells are known to suppress tumor promoting action of Immune and other tumor stromal cells. Cancer is a group of characteristic disorder which shows ―out-of -control ―growth of cells and division. In contrast to a normal cell, a cancerous cell follow damaged or altered pattern that make a cell tumorous. When tumor spreads all over the body, it grows, invade other healthy tissues, difficult to treat. The present investigation proved that the ethanol extract of Andrographis paniculata significantly suppresses the growth and induces apoptosis in Liver cancer Cell lines (Hep G2).
Keywords: KEYWORDS: Andrographis Paniculata; Hep G2 Cell Lines; Apoptosis.
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