Abstract
EVALUATION OF HEPATOPROTECTIVE EFFECT OF MORIN AGAINST DOXORUBICIN INDUCED HEPATOTOXICITY IN WISTAR RATS

Santhoshkumar Gunda* and Manmeet Kour S.

ABSTRACT

Doxorubicin (DXR) is an anticancer used in treatment of various malignancies and it is limited in use because of dose related toxic effects. DXR induced hepatotoxicity is caused by generation of free radicals and induction of oxidative stress which leads to cellular damage. In combination of antioxidants can be prevent liver damage. In the study it is investigated the hepatoprotective effect of Morin on DXR induced hepatotoxicity in wistar rats. Rats were divided randomly and protocol was followed in Control group (0.9% (Nacl) saline), DXRcontrol group (alone 25mg/kg interperitoneal (i.p)), DXR+Morin50 group (single dose 25mg/kg (i.p.) and orally 50mg/kg b.w.),DXR + Morin100 group (single dose 25mg/kg (i.p,) and orally 100 mg/kg b.w.), DXR+silymarin(std)( single dose 25mg/kg (i.p.) and orally 60 mg/kg b.w.). In treated groups doses were administered 3 times/week for 3 weeks. After 21 days, blood was collected and the liver is excised for biochemical analysis and histopathological examinations respectively. The serum parameters SGOT, SGPT, ALP and TBL are estimated. The tissue levels of catalase, superoxide dismutase (SOD), lipid peroxidation (LPO) were determined.Treatment with Morin significantly increased the antioxidant enzymes and structural damage to liver is reversed compared with DXRcontrol group, was found decreased the antioxidant enzymes and structural damage of liver. Results also shown similar hepatoprotective effect as Silymarin(std) as reference The results clearly suggest that Morin prevents hepatotoxity induced by DXR.

Keywords: Doxorubicin Morin.


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