European Journal of Biomedical and Pharmaceutical Sciences

NANOPARTICLES ENHANCING DRUG THERAPEUTIC EFFICACY

Rajiv Kumar (Arora)*, Monika Kaushik, Vivek and Parveen Ruhil

ABSTRACT

From the last two decades, there has been a great interest in the research area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Nanoparticles formulations have many advantages over traditional dosage forms, such as increased dissolution properties and the potential for intracellular drug delivery. Specifically, pure drug nanoparticles, polymeric nanoparticles and polyelectrolyte complexes offer some encouraging results for delivering drugs to various organs and through various routes. Various polymers have been used in the formulation of nanoparticles for drug delivery to improve therapeutic benefit, while minimizing side effects.

Keywords: nanoparticle formulations; drug delivery.