SUSCEPTIBILITY PATTERN OF SECOND LINE ANTIBIOTIC COLISTIN AGAINST GRAM NEGATIVE BACTERIA CAUSING URINARY TRACT INFECTION IN SELECTED AREAS OF DHAKA CITY, BANGLADESH
Mohammad Asaduzzaman*, Kamalesh Baral, Md. Mafizul Islam, Md. Abu Nayem, Md. Jahangir Alam, Farha Matin Juliana, Nazmul Hossain, Biswajit Das, Runa Asma and Sumaiya Jannat Tapati
ABSTRACT
In a few decades, infections like Urinary Tract Infection (UTI) caused by multi-drug resistant (MDR) pathogens have become a serious problem, especially in the nosocomial setting. The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial infections is a growing problem worldwide. The World Health Organization (WHO) has identified antimicrobial resistance as one of the three most important problems for human health. We know that Colistin was first introduced in 1952 and was used until the early 1980s for the treatment of infections caused by gram-negative bacilli. Colistin has identified excellent activity against various gram-negative bacteria in vitro. Our aim was to assess the susceptible pattern of Colistin which also known as polymyxin E, is an antibiotic against gram negative bacteria causing Urinary Tract Infections. A total of 9178 urine samples were collected in 2016 (January-December) and out of which 837 (9.12%) were bacteriologically (Gram Negative Bacteria) positive. Male was found more prone to get UTI under 10 years and between 51-80 years of age and female was more affected in 10 to 50 years and over 80 years of age group. E. coli was the most prevalent (89.3%) isolate followed by Klebsiella spp. (7.5%), Pseudomonas spp. (2.3%) and Proteus spp. (0.9%). The most predominant sensitive organisms to Colistin were Klebsiella spp. (100%) in both male and female and resistant organisms Pseudomonas spp. (33.3%) and E.coli. (22.1%) in male and female found respectively.
Keywords: Colistin, Polymyxin, UTI, Gram negative bacteria, Resistance, Uropathogen.
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