EVALUATION OF CYTOTOXIC ACTIVITY OF CHORDA FILUM FROM THE LEBANESE COAST AGAINST MCF-7 CANCER CELL LINE
Mona Y. Tannoury*, Myriam Khayrallah, Antoine M. Saab, Mona Diab-Assaf, Francine Rizk, Aline Hamadé* and Fadia Najjar
ABSTRACT
The discovery of cancer drugs and the identification of agents that effectively destroy cancer cells or stop their growth without toxicity to normal cells, and reduce the opportunity for the development of drug resistance by cancer cells and reduce side effects would have an important impact on cancer therapy. Many studies have demonstrated the anti-cancer effect of natural materials from marine resources especially marine algae that elicit unique and unexpected biological activities. In this report, we investigated the cytotoxic activity of a crude extract from Chorda filum (Chordaceae), a marine brown algae collected from the Lebanese coast, against MCF-7 human breast cancer cell line using trypan blue exclusion test. This ethanol-acetone extract showed cytotoxic activity against MCF-7 cancer cell line with IC50 value of 15,373 μg/ mL after 48 hours of treatment. Further research designed to isolate and identify novel and efficient anticancer drug candidates from this seaweed extract need to be explored.
Keywords: brown algae; Chorda filum; cytotoxic activity; MCF-7; trypan blue exclusion test.
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