REVIEW: ANTIDEPRESSANT MEDICINAL PLANTS
Dr. Nilofar S. Naikwade*, Gajanan S. Patil, Dr. Padma L. Ladda, Tabassam S. Shikalgar, Sudhir S. Patil, Ramchandra M. Dolare
ABSTRACT
Depression is not a life threatening disease but its consequences can obliterate a life of the suffered person. Depression is considered as an affective disorder which is characterized by change in mood, lack of interest, psychomotor retardation and melancholia. World Health report said that the approximately 450 million people suffer from a mental or behavioral disorder. Diagnostic and Statistical Manual of Mental Disorders (DSM-V), characterized Mental disorder by symptoms like depressed mood, diminished interest or pleasure, significant increase or decrease in weight or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, fatigue, feeling of worthlessness or excessive or inappropriate guilt, inability to concentrate or indecisiveness, and suicidal thoughts. The main etiology of depression is due to functional deficiency in the level of monoaminergic neurotransmitters like dopamine, serotonin and noradrenaline in the brain. Many synthetic drugs are being used as the typical treatment for clinically depressed patients, but their adverse effects can compromise the therapeutic treatment. These conditions create an opportunity to find alternative treatment for depression by the use of medicinal plants. The aim of present review is to gather the collective information about traditional medicinal plants having potential antidepressant activity. This review article also take account of the essential information regarding experimental models used to screen the medicinal plants whose leaves, fruits, stem, aerial parts, roots, rhizomes were utilized to evaluate the activity from various research articles.
Keywords: Depression, Antidepressants, Medicinal Plants, Forced Swim Test, Tail Suspension Test.
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