ANALYTICAL METHODS FOR CANGLIFLOZIN: REVIEW
Deepali Kailas Kadam*, Dr. Ravindranath Bhanudas Saudagar, Dr. Sarvesh Kumar Paliwal and
Dr. Swapnil Sharma
ABSTRACT
Analytical methods development and validation play important roles in the drug discovery as it is continuous and
inter-dependent task associated with development and Manufacture of pharmaceuticals. Method development is
the process of proving that an analytical method is acceptable for use to measure the concentration of an API in a
specific compounded dosage form which allows simplified procedures to be employed to verify that an analysis
procedure, accurately and consistently will deliver a reliable measurement of an active ingredient in a
compounded preparation. An effective analytical method development and its validation can provide significant
improvements in precision and a reduction in bias errors. It can further help to avoid costly and time consuming
exercises. Canagliflozin, being a Sodium Glucose co-Transporter type 2 (SGLT2) Inhibitor, as a new class for
treatment of Type 2 diabetes mellitus, offer a novel mechanism of action, which has been recently approved by
USFDA for use in type 2 diabetes mellitus, either alone or in combination with other oral hypoglycemic agents
and insulin. The aim of this review is to focus on comprehensive update different analytical methods developed
for Canagliflozin in bulk and in pharmaceutical preparations either alone or in combination with other
hypoglycemic agent.
Keywords: Canagliflozin, HPLC, HPTLC, UV, LC-MS/MS, UPLC-MS/MS.
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