European Journal of Biomedical and Pharmaceutical Sciences

NIOSOMES: A NOVEL FORMULATION FOR ANTI-AGEING COSMECEUTICALS

Mohammad Atif*, Satya Prakash Singh and Arun Kumar

ABSTRACT

Niosome is non-ionic surfactant-based liposome having particle size ranges from 10nm-100nm. They are formed generally by cholesterol incorporation as an excipient. Supplementary excipients can also used. Niosomes have more penetrating ability than the others preparations of emulsions. Aged skin has uniqueness like loss of skin tone with loss of elasticity, raise in dryness & roughness, rough pigmentation, wrinkles, sunburn and different malignant skin cancers. A large amount used delivery systems are liposomes and they are being used in a variety of skin care rejuvenating products. Niosomes adsorb on to cell surface with minute or no internalization of either aqueous or lipid mechanism, it may take place by two reasons, that is attracting physical forces or as a result of binding by specific receptors to ligands on the vesicle membrane and then transfer of drug directly from vesicles to the skin. Niosomes may fuse with the cell membrane, which leads to complete mixing of the niosomal contents with the cytoplasm. Lastly, by the process of endocytosis, niosomes may be engulfed by the cell thus releasing the entrapped drug into the medium

Keywords: Niosome, Anti-ageing, Pigmentation, Wrinkles.