European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF CORRIANDER SATIVUM EXTRACT ON MICRONUCLEUS FORMATION IN BONE MARROW CELLS OF SWISS ALBINO MICE

Rubal Chandrakar and *Wasim Raja

ABSTRACT

Coriander (Coriandrum sativum L.) being an annual herb is most commonly used for seasoning purpose. Its plant seeds, leaves and roots are edible, although they have very distinct flavors and uses. Coriandrum sativum Linn is a widely used medicinal plant throughout India and popular in various Indigenous System of Medicine like Ayurveda, and Siddha. Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. In this study, the protective effect of Corriander sativum extract has been tested against cyclophosphamide (CP)-induced micronuclei formation in mouse bone marrow cells. The three test doses, namely 100, 150 and 200 mg/kg body weight of Corriander sativum extract provided protection when given 24 hr prior to the single ip administration of cyclophosphamide (50 mg/kg body weight). A dose dependent inhibition of micronuclei formation was observed which was statistically significant (p<0.05) as compared to the cyclophosphamide group. It was observed that Corriander sativum extract alone could not induced micronuclei formation at the test dose 100 mg/kg body weight. Therefore, it‟s seemed to have a preventive potential against CP-induced micronuclei formation in Swiss mouse bone marrow cells.

Keywords: Corriander sativum, Micronucleus, Mutagenic, Genotoxic.