HEPATOPROTECTIVE POTENTIAL OF POLYHERBAL FORMULATION AGAINST ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY ON RATS
M. Karthikeyan* and V. Gopal
ABSTRACT
The first line anti-tuberculosis drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and Ethambutol(ETH)continues to be the effective drugs in the treatment of tuberculosis, however, the use of these drugs is associated with toxic reactions in tissues, particularly in the liver, leading to hepatitis. This is one of the most serious adverse effects of anti-tuberculosis drugs (ATD). Currently, there is no effective treatment against ATD induced hepatic damage. Plants are an important component of the health care system in India and have been found to be effective in the treatment of different diseases. Hence the present study was undertaken to explore the use of Poly herbal formulation as a hepatoprotective formulation against Anti TB drugs induced hepatic adverse effect. The botanical species of Eclipta prostrata, Wedeliac hinensis, Centella asiatica, Acalypha indica, Indigofera tinctoria and Sphaeranthus indicus were collected from rural areas of Thanjavur, Tamil Nadu, India. Obvious hepatic injury was observed after the treatment of rats with the anti-TB drug for 45 days. Polyherbal formulation showed a significant protective effect on anti-TB-induced liver injury. The hepatoprotective action of Polyherbal formulation might be associated with its ability to attenuate oxidative stress. The current evidence from experimental studies demonstrates that supplementation of KKC has potential hepatoprotective and antioxidant activity against anti-tubercular drugs induced hepatotoxicity on rats.
Keywords: Polyherbal medication, Antitubercular drugs, hepatoprotective plants, phytoconstituents, Karisalai Karpa Chooranam.
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