Abstract
IN-VITRO, EX-VIVO SKIN PERMEATION AND BIOLOGICAL EVALUATION OF BOSWELLIC ACID TRANSDERMAL PATCHES

Prachi M. Patel*, Dr VH Bhaskar and Unnati Gohel

ABSTRACT

Objective: Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. Boswellic Acid (BA) is chemically pentacyclic triterpenoid which possess powerful anti-inflammatory action. The present study was designed to formulate BA transdermal patches using different polymers. Method: Matrix type Transdermal Patch of BA with Piperine as bioenhancer was prepared using solvent casting technique. The BA patches were evaluated for in-vitro and ex-vivo drug permeation through cellophane membrane and rat skin respectively. The biological evaluation regarding skin irritation study and the anti-inflammatory effect of BA patches on rat paw edema were tested and compared with standard Aceclofenac transdermal patch. Result: The following were the principal findings of this research. The matrix type patch of F10 formulation, containing 200mg polymer (HPMC K15M), 5% menthol (Permeability enhancer), 30% glycerin (plasticizer) and 50mg piperine, was showed 97.8% in vitro and 93.20% ex vivo drug release at 10 h. The anti-inflammatory action F10 formulation showed no skin irritation with significant inhibition of rat paw edema compared with standard Aceclofenac transdermal patch. Conclusion: This study has supplied us with brightening results concerning the questionable equipotent therapeutic efficacy of transdermal BA versus standard Aceclofenac patch and not irritable to skin.

Keywords: Transdermal Patches, BA, Skin irritation test, Inhibition of edema.


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